As we know, drugs that target homologous proteins should be less promiscuous than those have demonstrable activity across different protein families [ 29].
We chose this pragmatic approach, in the absence of previous research in LMIC, given the difficulties of developing a more structured assessment with demonstrable validity across many different countries and cultures.
Combinations might best be assessed based on presence of demonstrable preclinical synergism across a wide range of cell lines, or based on presence of known targets for both agents, or based on a potential for the second agent being able to block an alternate growth pathway or resistance mechanism that might protect against the first agent.
Taken together, these findings show that Comt1 B2i (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity (comparable to the human Val-Met polymorphism) which has a demonstrable behavioral phenotype across a variety of outbred genetic backgrounds.
Well, admittedly, the Times said "demonstrable," not actually "demonstrated".
With the success of the public health model of service delivery and the demonstrable adherence of patients on treatment across the world, and especially in Africa, treatment for AIDS is saving and changing lives [ 30].
As far as A4e is concerned, the real and demonstrable impact we have on the lives of the customers across all our contracts – in employment, skills, training, health, money advice and legal aid – is not some happy accident on the road to making money.
15 Our trial reported included 760 patients across 21 centres (62% colorectal operations) and found no demonstrable benefit for any subgroup of patients.
This results in a large network of reactivities for each specific antibody across each of the members of the family; certainly with demonstrable variations in regards to avidity.
Globally, and across health disciplines, time, knowledge about the elements of quality guidelines, demonstrable incentives and accessibility to information on guidelines are universal barriers to implementing evidence in clinical guidelines into practice [ 10- 13].
