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There are patients of ABPA who otherwise fulfill all diagnostic criteria, but lack demonstrable abnormalities on CT chest.
Kerber et al. showed no demonstrable abnormalities of the LV contraction and perfusion functions after high-energy transthoracic shocks.
The Monoclonal Anti-TNF, A Randomized controlled Sepsis Trial (MONARCS) study used a different anti-TNF-α formulation (F [ab']2 fragment of a murine monoclonal antibody to human TNF-α), and stratified patients based on demonstrable abnormalities in immunological pathways (highly elevated interleukin-6 levels - a circulating cytokine that is induced by TNF-α).
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There is very real suffering involved in the anticipation, and the suffering can begin years before there is any demonstrable abnormality or disability.
We found that heterozygous Kif3a+/Δ mice had no demonstrable bone abnormalities (Fig. 2).
Currently available diagnostic techniques are unable to establish the genetic cause in at least 60% of suspected mitochondrial disease patients who have demonstrable biochemical abnormalities [26].
The possible mechanisms relating BMD loss and back pain remains elusive, as even in women with severe persistent back pain, the symptoms were only rarely associated with vertebral fractures or demonstrable radiological abnormalities [ 25].
These diagnoses are often characterized more by symptoms and distress, than by consistent demonstrable tissue abnormalities [ 13, 14], and are often based on the patients' own reports of pain and complaints [ 15, 16], and may be classified as subjective health complaints [ 13, 15, 16].
These children grow consistently close to or below the 3rd centile without demonstrable endocrine abnormality.
No additional genes were identified to be differentially expressed (FDR < 5%) between the three groups using the less stringently filtered dataset though there was a trend for BRCA1 and a gene that is positively regulated by BRCA1, AREG [ 22], to be expressed more highly in the group with no demonstrable BRCA1 abnormality compared to the other groups (Additional file 4).
Although ERT has a marked effect on non-neurological manifestations, it has no demonstrable effect on neurological abnormalities because the enzyme does not cross the blood-brain barrier (Vellodi et al., 2009).
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