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It is important to detect and effectively treat depression because the comorbidity of depression and cognitive impairment is associated with greater cognitive and functional decline and higher rates of institutionalization. Depression often can be differentiated from Alzheimer disease and other dementias based on characteristics of clinical history and presentation.
Although we used an assessment protocol that we have previously shown is highly accurate in distinguishing AD from other dementias based on post-mortem confirmation, it will be interesting in due course to correlate the behavior of our panel to specific markers of dementia pathology such as biochemical or imaging measures of Aβ and tau.
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The denominator for the primary analyses was based on current NCQA-HEDIS criteria that exclude individuals with cardiovascular conditions, end-stage complications of diabetes (blindness, amputations, and end-stage renal disease), and dementia based on one ICD9-CM or Current Procedural Terminology (CPT) code in either the calendar year or preceding year (1).
The strengths of the present study are the use of a community-based population, DSM-IV criteria for diagnosing dementia based on clinical assessments, and analysis of subgroups stratified according to age, sex, and education level.
BACKGROUND: Statins are being developed as treatments for Alzheimer's dementia based on evidence from preclinical and observational studies.
Now that's fairly widely accepted that you can make diagnosis of types of dementia based on regional areas of greater volume loss in the brain.
In the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) we aimed at creating a quantitative score for primary care physicians to define the risk of an individual for future dementia based on information that can be obtain in the primary care setting in acceptable time and at low costs.
We had originally set a sample of 80 persons with dementia, based on our estimates of how many individuals we were likely to be able to enrol given the time and human resources at our disposal and the geographical area of coverage of the program.
First, we excluded persons with dementia based on a detailed clinical evaluation.
Exclusion criteria are: (i) severe dementia (based on DSM IV-criteria); pathological fracture; or a peri-prosthetic fracture.
Participants were excluded when they had a dementia diagnosis or were suspected for dementia based on clinician's judgement.
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