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Participants with any CMB had 1.74 times higher risk of dementia (hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.00 3.01), whereas those with deep and mixed CMB had a three-fold increased risk (HR 2.99, 95% CI 1.52 5.90).
Small left hippocampal volume was significantly associated with later dementia (hazard ratio=2.762).
Waist circumference showed no obvious association with dementia hazard.
To determine if adiposity in later life increases dementia hazard.
Overweight men had lower dementia hazard than men with normal BMI.
Our results suggest that measures of adiposity are associated with incident dementia in later life, with the lowest dementia hazard falling within the overweight BMI range and WHR≥0.9.
Similar(44)
In the analysis restricted to users of centrally acting agents only, the estimated hazard ratio suggested a greater reduction in dementia risk (adjusted hazard ratio 0.84, 95% CI 0.71 1.00), but this is clearly limited evidence for any real difference given the wide confidence interval.
An analysis restricted to the first 12 months after the index date showed a larger effect on dementia risk (adjusted hazard ratio 0.60, 95% confidence interval 0.50 0.72).
In the fully adjusted analysis, drinking alcohol frequently was still significantly associated with increased dementia risk with a hazard ratio of 1.40 (1.40–1.40).
An exploratory analysis with ARBs thought to have the ability to affect the brain RAS suggests a possible larger reduction in the risk of dementia (adjusted hazard ratio 0.84, 95% CI 0.71 1.00).
A post hoc analysis was also conducted to verify whether the adjusted hazard ratio for dementia risk with ARB exposure varied with the time since starting treatment.
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