There was weak evidence of a decreased risk of dementia with exposure to angiotensin receptor blockers, with follow-up beginning at 1 year after the start of treatment (adjusted hazard ratio 0.92, 95% confidence interval 0.85 1.00).
We therefore suggest that the inverse association between dementia risk and exposure to ARBs is likely to be explained by noncausal factors.
With the repeat analysis of the risk of dementia with ARB exposure in the initial 12 months following the index date with the additional adjustment for stroke, the adjusted hazard ratio for dementia was 0.61 (95% CI 0.51 0.73).
To date there have been no randomized controlled trials that have examined the risk of developing cognitive impairment meeting clinical criteria for AD or related forms of dementia associated with exposure to GA.
This additional adjustment for the history of stroke was included in the post hoc analysis for the risk of dementia with ARB exposure for the follow-up period starting 12 months after the index date (same follow-up period as for the primary analysis) and also in the initial 12 months after exposure to ARB or ACEI.
Points were assigned as follows: two for recent hospitalization or ICU admission; one each for age < 30 or > 79 years, prior IV antibiotic exposure, dementia, cerebrovascular disease, female with diabetes, or recent exposure to a nursing home/long term acute care facility/skilled nursing facility.
Researchers estimate that one in 38 children in the United States still have harmful levels of the metal in their systems, but evidence linking this exposure to dementia later in life has been tenuous.
On the other hand, their failure to accept reality might be psychological, early onset dementia resulting from excessive exposure to Fox News and hate radio.
For example, delirium might be modeled as an exposure, with dementia as an outcome.
However, the relationship between risk factors and dementia involves a long exposure time.
