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Deng et al. [104] showed that using ANN can get higher sensitivity and accuracy than traditional discriminant function analysis [105] in dementia classification using MRI.
Thus, there is a strong demand for computer-aided automated dementia classification, which is expected to provide a useful "second opinion" and enable doctors to bypass the aforementioned issues.
The recent studies also suggest that deep learning, which is usually based on a hierarchical ANN, is effective in capturing high-level variations of brain images and improves the dementia classification [107, 108, 109].
A computer-aided automated dementia classification, thus, would provide a useful "second opinion".
Hence, feature selection plays a pivotal role in improving the performance of dementia classification.
We compared our GA-MKL algorithm to two state-of-the-art dementia classification methods on 129 clinical studies.
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The steps that were carried out for detection of the prevalence of dementia and classification of its subtypes are demonstrated in Figure 1.
In both procedures, ICD-10 was used to diagnose dementia; for sub-classification, ICD-10 was used for AD and VaD, McKeith criteria for dementia with Lewy bodies, and the Manchester Lund criteria for frontotemporal dementia.
Accordingly, we suggest this method as a diagnostic standard for the classification of dementia syndromes.
Rothschild also questioned the traditional classification of dementia.
Among these cases, about half are symptomatic and few meet research classification of dementia.
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