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The final highlight is Husbands, with Beth toggling between a coquettish Peaches rasp and a demented stage whisper for the chorus.
His Prospero was a demented stage manager on a theatrical island, suspended between smouldering rage at his usurpation and unbridled glee at his alternative ethereal power.
The Financial Times reviewer described him as "a demented stage manager on a theatrical island suspended between smouldering rage at his usurpation and unbridled glee at his alternative ethereal power".
The chronological relationship between prodromal stage and demented stage of AD has been evaluated in the PAQUID study [ 8].
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Cortical thinning is however, also present in non-demented late-stage PD patients [55], [58], [59], [60].
In the non-demented Braak-stage-IV Aβ-phase-4 case lacking AGD-pathology, only five neurons were retrogradely labeled in a 1-mm-thick slab of the area 35.
The reduction of the number of tracer-labeled association neurons in area 35 in the AD case and in the non-demented Braak-stage-IV case indicates that there was a disconnection between the temporal cortex of area 35 and the entorhinal cortex.
It may be too soon to get a conceptual statement from Yale Repertory's artistic director, Stan Wojewodski Jr., about the time line or the demented state of "Richard III" in the Yale School of Drama's staging to run March l8 through April 8.
In later stages, demented patients are helpless and require full-time nursing care.
Age-related cognitive change can be placed along a continuum from normal to severely demented, with intermediate stages of cognitive decline.
However, quantitative assessment of NFT in both frontal and temporal cortices revealed that these non-demented subjects showed less NFT compared with demented subjects with Braak stage V-VI [ 26] and demonstrated a considerable range of pathology within Braak stage VI [ 27].
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