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(5) Molecules with more than 6 undefined stereocenters were also removed because they need substantial computational resources to consider.
The alignment step is usually time-consuming, requiring substantial computational resources and demanding hours to align even one individual's RNA-Seq data.
Using a non-linear kernel proved to be infeasible for large data sizes, even with substantial computational resources on a computer cluster.
Hydrodynamic models generally deal with large sets of data and utilize substantial computational resources.
The complexity, granularity and dimensionality of the problem require of substantial computational resources that are not affordable by regular CPU-based architectures.
A possible method to address this issue is to replace the analytical partial derivatives by a numerical method; however, this may require substantial computational resources.
They also have access to substantial computational resources needed to analyze massive data sets.
In a partitioned approach for computational fluid structure interaction (FSI) the coupling between fluid and structure causes substantial computational resources.
However the algorithm is highly accurate (see experimental results), but it requires substantial computational resources.
Despite algorithmic improvements, rip2 still requires quite substantial computational resources for practical applications.
Also because SMAP is a method requiring substantial computational resources, the number of screens that could be performed was limited.
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