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If the stress or insult is severe, if oxygen availability is limited and the increased ATP demand is severe, the decrease in ATP induces apoptotic or necrotic cell death, depending on specific intracellular ATP levels (Fig. 5B).
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We are deeply and fundamentally attracted, in fact, to games: those places where efforts and excellence are rewarded, where the challenges and demands are severe, and where success often resembles nothing so much as a distilled version of the worldly virtues of dedicated learning and rigorously co-ordinated effort.
This view was expressed following a presentation by the managing director of South-West Trains, who said that overcrowding is severe with demand having more than doubled to an annual 230 million passenger journeys since 1995 and expected to rise by a further 40% in the next 30 years.
Even indirect methods of estimation prove useful in returning empirical estimates of demand responsiveness were severe data constraints exist.
"There is severe impairment".
Unemployment is severe.
The shortage is severe.
The problem is severe.
For many, the sports problem is severe.
But advocates here say that aspects of Spain's procedures — how quickly banks can foreclose, the interest rates they can charge and the repayment schedules they can demand — are particularly severe.
The tool selected for assessing this severe demand is the reduction in the buckling load capacity (stability) of the structure under service loads.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com