In the Fund's view the medium-term looks subdued because of "a chronic lack of demand, impaired corporate and bank balance sheets, and deeply rooted structural weaknesses".
The latter two observations have led to the concept that microvascular injury, impaired microvascular control, and maldistribution of microvascular blood flow induce a tissue oxygen debt [ 8], and the theory that inefficient matching of microvascular oxygen supply (qO2) to oxygen demand (dO2) impairs oxygen extraction [ 9, 10].
Fecal coliform bacteria, total solids, and biochemical oxygen demand also impaired water quality.
Therefore, high body mass requires greater foraging time and metabolic demands and impairs flight capabilities, negative factors that would increase predation risk.
Potential mechanisms include malnutrition, decreased haematopoietic cell production, diminished capacity of the haematopoietic stroma to respond to increased demand, and impaired erythropoietin feedback secondary to excess inflammatory cytokines[1], [12] [15].
It is as yet unclear whether cerebral hypoperfusion is the cause (i.e. through moderate ischaemia) or the consequence (i.e. through reduced demand) of impaired cognition.
When intensively proliferating cells form a solid tumour, the balance between oxygen supply and demand is impaired; therefore, hypoxic environments (intratumoural hypoxia) prevail in growing cell masses.
Cardiac dysfunction with haemodynamic instability in combination with an increased cerebral metabolic demand and impaired cerebral autoregulation could contribute to a cerebral oxygen supply/demand mismatch with an increased risk of cerebral infarction.
This results from an imbalance between high metabolic demands and impaired tissue perfusion due to microvascular damage.
Although high cognitive demand conditions can impair psychological, physical, and behavioral processes without appropriate management, current measurement methods are too cumbersome for continuous monitoring of cognitive demand, and do not account for individual differences.
