"This is not a time for unreasonable expectations or demands or breakthroughs on either side".
That deadline means a trade deal must be concluded this year which in turn demands a political breakthrough now.
In the leafy suburbs, I am pursued by the "worried well"; requesting ever more screening, demanding the latest "breakthrough" treatment, attentively listening to advice on medications and lifestyle, and presenting requests for prescription repeats well ahead of time.
These logistical breakthroughs demand the integration of a suppliers operations and information so that, for example, Kmarts shelves are automatically resupplied in response to real-time data sent to Coke and Pepsi.
Immunex had badly underestimated demand for Enbrel, its breakthrough drug for rheumatoid arthritis.
"It appears that instead of concentrating his focus on the need to carefully conduct clinical trials that the introduction of a breakthrough medicine demands, ImClone was more focused on the sales pitch," said Representative James C. Greenwood, the chairman of the subcommittee.
That both flattered him and demanded the next great breakthrough from his laboratory.
By giving it out selectively, you can control who has that kind of breakthrough, on-demand access to you.
Late stage marketable technologies will draw 10% demand while early stage breakthroughs will only garner perhaps 1%.
The proposed mathematical model is found to be robust and accurate for optimization of time-lagged coating formulations for programmable pulsatile release of ranitidine hydrochloride, consistent with the demands of nocturnal acid breakthrough.
