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While reported instances of exosomal transfer have demonstrated endogenous cellular protein, and more recently RNA, as microvesicular cargo [39], data presented here for the first time suggest that such a transfer pathway can be actively targeted for delivery of replication deficient particles.
EGFR genetic deficiency, pharmacological inhibition of EGFR signaling, or adenoviral delivery of the kinase-deficient EGFRK721A construct effectively blocked colchicine-stimulated expression of two prominent vascular profibrotic genes, plasminogen activator inhibitor type-1 (PAI-1; SERPINE1) and connective tissue growth factor (CTGF; CCN2).
Supportive and contradictory data to the hypothesis that deficient delivery of fast-transported proteins to the axon causes, or contributes to, neurotoxicity are critically summarized.
Salomon et al. reported a low frequency of bleeding complications after delivery in severe deficient patients.
The scheduling and delivery of data packets in a deficient method may probably cause network congestion, which will in turn decrease the capability of QoS provisioning in the network.
We considered two possibilities to explain the constitutive presence of autophagosomes in RNAi-AtTOR plants: either the decreased expression of AtTOR leads to the constant formation of autophagosomes, or the RNAi-AtTOR plants are deficient in delivery of autophagosomes to the vacuole for degradation.
Noteworthy, trans-translation deletion mutants of Y. pseudotuberculosis are deficient in the delivery of Yop proteins by a Type III secretion system [24].
The expression of NHL3 was suppressed in Arabidopsis upon inoculation with a virulent Pseudomonas syringae (Pst DC3000); however, inoculation with a mutant Pst DC3000, which is deficient in the delivery of effector proteins of the Type III-secretion system, induced the expression of NHL3 [ 45].
In contrast to the wild-type, AgtA-GFP almost exclusively localized to the plasma membrane in didBΔ cells cultured on glutamate because the labeling of vacuoles seen in the wild-type was markedly less conspicuous in the mutant (Fig. 3A, lower left), strongly indicating that delivery of AgtA to the vacuole is deficient.
Utilising adenoviral delivery of IL-18 and TNFα/IL-1 deficient mice, Joosten and colleagues subsequently demonstrated that whilst IL-18-induced joint inflammation is independent of IL-1, cartilage degradation requires IL-18 induced IL-1β production [ 18].
We also observed delayed delivery of PDGFR to lysosomes in MCOLN1-deficient cells.
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The phrase "delivery of deficient" functions as a noun phrase , where "delivery" is the noun and "of deficient" acts as a prepositional phrase modifying it. It describes the act of providing something that is lacking in quality or quantity. Although Ludwig doesn't provide specific examples, similar phrases highlight this descriptive function.
Expression frequency: Missing
