Sentence examples for delivery of aggregated from inspiring English sources
The SIV fragments tested were selected because they are key immunogens examined as relevant gene products in other published research [ 14, 15] Those studies had shown toxoids of Tat or Tat and Rev, or delivery of aggregated multiantigens, provided some disease attenuation [ 5, 6] whereas use of Tat alone for example, provided only temporary infection containment.
In a concentration- and buffer-dependent manner, one could ask how these modifications affect the solubility and delivery of aggregated protein.
Delivery of aggregates to applications may be performed periodically.
These results demonstrate that the intramuscular delivery of 3D cell aggregates of HUVECs/cbMSCs can be a valuable cell-based regenerative therapeutic strategy against MI.
Sequestosome 1 (P62/SQSTM-1) is a multi-functional adaptor protein, which interacts with ubiquitinated proteins and is thought to be involved in the delivery of ubiquitinated proteins/protein aggregates to both the ubiquitin proteosome system (UPS) or autophagosome for degradation [59].
ROS serves as a critical signaling molecule in a variety of cellular processes, including cell proliferation, survival, differentiation, and programmed cell death., Autophagy can reduce ROS levels via SQSTM1/p62-mediated delivery of oxidized protein aggregates to autophagosomes., We find that sh Becn1-MSCs produce more ROS than control MSCs in the inflammatory microenvironment.
A combination of factors associated with the drug therapy, including route of delivery, vehicle, the presence of aggregates, the presence of innate immune system triggers, frequency of dosing and the ability of the protein to interface with the humoral (B cell) and cellular (T cell) immune systems, all impact potential immunogenicity.
Delivery of pBMP-2 within Donor 1 aggregates promoted chondrogenesis at week 2, followed by an enhanced osteogenic phenotype at week 4. Donor 2 and 3 aggregates did not promote robust glycosaminoglycan (GAG) production at week 2, but by week 4, Donor 2 aggregates with pTGF-β1/pBMP-2 anDonoror 3 aggregates with both unloaded MCM and pBMP-2 enhanced osteogenesis compared to controls.
Total number of woodlice aggregated, possibly in several aggregates.
This open aggregate hydroponic system permitted accurate and uniform delivery of nutrient solutions.
Both stages of the antibody response--the induction of helper T lymphoblasts by dendritic cells and the delivery of help from T to B cell--occur in discrete cell aggregates that can be isolated by velocity sedimentation.
