Although DTNs are not the cytotoxicity factor, the delivery effect for AS1411 was proved.
Dual-ligand system may possess a synergistic effect and create a more ideal drug delivery effect.
To enhance gene delivery effect, various cationic complexes have been developed for delivering plasmid DNA, antisense, or siRNA into cells [7 9].
The earlier hopping of γ-globulin uptake rate was attributed to its larger size and less net charge, which facilitated the happenings of the "chain delivery" effect.
The results indicate that both PEI layer and protein size played important roles in protein adsorption to PEI-grafted resins, and further prove the "chain delivery" effect did contributed significantly to the uptake rate hopping in the PEI-grafted resins.
In order to determine the influence of non-endocytotic delivery effect on the transfection efficiency of rHDL/CD-PEI/pEGFP-C3 complexes, the in vitro transfection and expression of GFP were qualitatively and quantitatively analyzed by inverted fluorescence microscopy and flow cytometry, respectively.
The adsorption and elution behaviors of bovine serum albumin (BSA) on poly ethylenimine) (PEI -grafted SePEI -graftedeSepharose recently studied and a critical ionic capacity (cIC; 600 mmol/L) was FFund, above which the uptake resinsncreased drastically due to the occurrence of significant "chain delivery" effect.
It is considered that the occurrence of the drastic uptake rate increase in FF-PEI-R440 was attributed to the decreased available binding sites for protein molecule, which led to the decrease of binding strength, thus facilitated the happenings of "chain delivery" effect of bound proteins.
The acidic pH increases the cellular uptake of weakly acidic drugs, thereby increasing the delivery effect of the drug to the target site.
Objective(s): To investigate whether the mode of delivery effects the birthweight.
For all pharmaceuticals, precise determination of pharmacological parameters, such as the absorption, transportation, target delivery effects, blood circulation time, clearance half-life, organ biodistribution, and accumulation, are essential prerequisites for them to be developed into practically usable drugs [46].
