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Data regarding the planned and delivered weekly dose intensity of treatment, the overall treatment dose delivered, toxicity and clinical outcome were collected.
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AgNPs have a large surface area-to-volume ratio, which means they potentially provide an efficient means of delivering toxicity.
Correlations between the absorbed doses delivered and toxicity and response have been reported both for hepatocellular carcinoma [33 35] and colorectal metastases [36, 37].
The relative dose intensity (calculated from FOLFIRI3-b initiation to the last course of chemotherapy delivered before toxicity, disease progression, surgery, or the planned 12th cycle of FOLFIRI3-b) was 88% for Irinotecan, 85% for 5-FU, and 87% for bevacizumab.
Taken together, the role of some of the receptors in delivering the toxicity in target organisms seems to be well established.
This suggests that active treatment of elderly GBM patients with RT can be delivered without significant toxicity and with a significant survival benefit.
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately.
However, relevant data can be collected by simply performing post-therapy imaging and dosimetry routinely in current practice and by comparison of the absorbed doses delivered with response and toxicity data.
Of these designs, the gapmer ASOs emerged as lead compounds for silencing ADAM33 expression: several gapmer ASOs showed subnanomolar potency when transfected with cationic lipid and low micromolar potency with no toxicity when delivered gymnotically.
A total of 1122 PET courses and 386 ET courses were delivered and analysed for toxicity.
Although it was shown to be effective in boosting antitumor immunity, IL-2 can be associated with unacceptable toxicity when delivered systemically [ 24].
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