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The chemotherapy was delivered selectively to the tumor cells using intratumoral (i.t).
The chemotherapy was delivered selectively to the tumor cells using intratumoral (i.t.) injection of the AdCDIRESE1A vector followed by intraperitoneal (i.p.) 5-fluorocytosine (5FC).
Whereas directly labeled antibodies, fragments, and subfragments (minibodies and other constructs) have shown promise in both imaging and therapy applications over the past 25 years, their clinical adoption has not fulfilled the original expectations due to either poor image resolution and contrast in scanning or insufficient radiation doses delivered selectively to tumors for therapy.
Of course, when applied as a therapy, such chemo-sensitization must be delivered selectively to the tumor cells, since normal tissues could also depend on the same DNA repair pathway.
In the GDEPT approach, the gene encoding the enzyme is delivered selectively to tumour cells.
Thus if these agents could be delivered selectively to tumour cells, the 'holy grail' of an effective anti-cancer drug with minimal peripheral toxicity would be a reality.
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ECM proteins can also serve as anchors to deliver selectively to tumors and/or metastases imaging probes to enhance the detection of metastases or anti-tumor agents to enhance therapy on the model of the work pioneered by Neri et al. (Pasche and Neri, 2012).
Stability studies uncovered that all lipophilic prodrugs delivered PMEA selectively by chemical means.
We therefore used DAT-KO mice to test a novel combinatorial viral strategy aimed at restoring proper DAT expression and function by means of brain delivery of recombinant Adeno-Associated Viruses (rAAVs) engineered to deliver genes selectively to dopaminergic neurons.
Therapeutic approaches that exploit nanoparticles to deliver drugs selectively to cancer cells are currently considered one of the most promising avenues in the area of cancer therapeutics and imaging.
Hydrodynamic focusing, where one fluid stream is tightly constrained between two others, has also been used to deliver solutes selectively to subpopulations of cells [19].
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