In summary, l-OHP containing PEG-coated cationic liposomes induced significant tumor growth suppression, presumably by delivering encapsulated l-OHP into both tumor endothelial cells and tumor cells.
Our approach, as a proof of concept to improve drug transport through the BBB, is based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles with surface functionalized with anti-transferrin receptor monoclonal antibody (OX26) and anti-Aβ (DE2B4) to deliver encapsulated iAβ5 into the brain.
Another novel method to deliver encapsulated drug is vesicular system, which means the colloidal particles containing concentric bilayer, capable of transporting both hydrophilic and hydrophobic drugs.
In addition, Anand et al. (2010) used PLGA-poly-ethylene glycol nanoparticles to deliver encapsulated curcumin with 97.5% efficiency but low drug loading [ 39].
This nanoparticle system is noncytotoxic, is nonimmunogenic, and has been shown to effectively deliver encapsulated disease-modifying anti-rheumatic drugs (DMARDs) and surface-coated NF-κB decoy ODNs when applied to in vitro models of RA and cystic fibrosis (CF), respectively [ 24, 25].
One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degradable, polymeric microspheres.
It has been reported that rHDL could specifically deliver its encapsulated payload into the cytoplasm via the non-endocytic pathway [16].
Fusogenic liposomes effectively and directly deliver their encapsulated contents into the cytoplasm using a fusion mechanism of the Sendai virus, whereas conventional liposomes are taken up by endocytosis by phagocytic cells of the reticuloendothelial system, for example macrophages and neutrophils.
These structures can be used to deliver drugs, encapsulate tools like CRISPR-Cas9 gene editing elements, or even store information.
In this study, HPV-infected cervical cancer HeLa cells were employed to investigate the effects of ATO when delivered in free or encapsulated in liposomes.
