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Other candidate Arg-rich peptides (such as Pip peptides and B-MSP) also utilize R-Ahx-R or R-β-R (β = beta-alanyl) motifs and have been used successfully to deliver PMO with even higher activity in mdx mice (16, 17).
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However, we and others recently reported that the PPMO and Vivo-PMO were able to deliver the PMO oligomers effectively into near 100% of skeletal and cardiac muscles of the mdx mice without notexin pretreatment [7], [8].
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