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"Harnessing the extremely high conductivity, superb strength, very low weight and ultimate flexibility of graphene, Paragraf's technology is the first ever commercial-scale method validated to reproducibly deliver functionally active graphene with properties targeted to its final device-specific application, with both high quality and high throughput," is the team's claim for their approach.
Through systematic structural modifications to the hydrophilic head group we have modulated the apparent acid dissociation constant (p Ka) of the ionizable amino lipids present in the LNPs and investigated the relationship between the p Ka value and activity, that is, the ability of the LNPs to deliver functionally active siRNAs into hepatocytes for eliciting gene silencing in vivo.
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It's a clever, artfully designed concept which delivers, functionally and atmospherically.
The enhanced uptake of siRNA was corroborated by improved silencing of both gene- and protein expression of VE-cadherin in activated HUVEC, indicating that SAINTarg delivered functionally active siRNA into endothelial cells.
By combining a sequence of 16 lysine residues (K16) with the signal peptide (SP) sequence of Kaposi's fibroblast growth factor (K-FGF), we have synthesized a peptide (K16SP) that efficiently and noncovalently delivers functionally intact proteins (immunoglobulin G molecules, β-galactosidase, and green fluorescent protein) into mammalian cells.
Acute care for elders units (ACE) focus on early rehabilitation, discharge planning, and delivering functionally oriented, patient-centered care [ 1, 2].
The design of safety critical systems frequently necessitates to simultaneously fulfill several logical and numerical constraints as requirements in order to deliver a functionally correct and optimal target system.
These results prove that prevascularized cell sheets were able to form extensive vascular networks in vivo and that those prevascularized networks could anastomose with the mouse vascular system and functionally deliver blood.
The in vitro release rate reflects how the semi-solid formulation functionally delivers tenofovir from the dosage form.
The first RNAs to be proven as functionally delivered and translated by microvesicles were mRNAs originating from mouse mast cells.
Here functioning perilesional left hemisphere cortex was identified using fMRI pre-treatment to ensure that tDCS was delivered to both functionally and structurally viable cortical tissue.
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