We reasoned firstly, that use of a ligand-induced protein conformation in a subsequent rigid docking protocol should deliver a similar binding mode for compounds similar to the docked ligand; and secondly that the binding mode of a ligand obtained using flexible docking should be reproduced by rigid docking into the protein conformation induced by that ligand.
Only this can deliver a legally binding treaty which puts the world on a trajectory to a maximum global average temperature increase of two degrees and provides a fair deal for developing countries".
After two weeks of exhaustive talks, world leaders failed to deliver a legally binding commitment to cut greenhouse gas emissions, instead producing just a two-page accord saying future temperature rises should be limited to 2C.
It comes days after Mr Salmond and the Prime Minister signed a deal which will deliver a legally binding referendum on independence in 2014, with David Cameron pledging to campaign to keep the United Kingdom "family" together.
But, as hard as they may try, it is simply not in the gift of civil servants in Brussels to deliver a legally binding promise to revise the postwar European treaties, before a formal process of revision has begun.
Many developed nations are not in a position to deliver a legally binding deal due to various reasons.
There is heavy pressure on the United States and other countries like the EU, Denmark, Canada and Australia to deliver a "legally binding" agreement at the upcoming UNFCCC summit in Copenhagen, Denmark scheduled for mid-December.
In our study (Oehlmann et al. 2006), we did not intend to deliver a complete binding study in which saturation experiments with Scatchard analysis are needed, but to provide indications for the presence of estrogen receptors by a specific binding of ligands to cytosolic extracts (a widely used practice).
The child protection regulations will deliver a legally binding set of multi-disciplinary procedures that provide standards for identifying, referring and responding to cases of child abuse, as well as the roles and responsibilities of all concerned agencies and competent officers.
