Due to the spatial aggregation effect, the amount of zones (AoZ) has a direct influence on the optimality of traffic analysis zone delineation (TAZD) problems.
With perfect recall of every past patient interaction and the ability to integrate dozens of seemingly disparate criteria into a diagnosis, he noted, "a computer could potentially come up with a much more specific delineation of a problem".
Since ultimately everything is part of other bigger systems, systems thinking poses problems of delineation (at what level to tackle the issue) andof measurement (how best to measure performance of a system, the NHS, say).
The problem of WMH delineation is further complicated by the fact that other pathological features (i.e. stroke lesions) often also appear as hyperintense regions.
To overcome this problem, several automatic delineation methods have been proposed [18 23], but up to the present, no general consensus about the best method exists.
This delineation is part of the problem statement, but is a limitation of the study.
Moreover, as has been demonstrated for other millipede groups [e.g., Jamaican Anadenobolus; [ 35, 36]], cryptic species may be a problem for species delineation within this genus.
First reports on the use of MR images for brachytherapy treatment planning of cervical cancer were published in 1992 when Schoeppel et al. discussed the problem of tumour delineation on MR images after external irradiation.
Rarity is not only a theoretical problem in species delineation methods, but hinders assessment of genetic variability [ 16, 28]; if populations with intermediate haplotype composition are left unsampled, barcoding and molecular-based species delineation approaches tend to overestimate species [ 18, 27].
Two important problems are the delineation of areas where the variable is above the detection limit and the estimation of the magnitude of the variables inside those areas.
