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However, at high contrast, these delineation errors are very small.
This method produces polar plots (max-count polar maps) that are less affected by delineation errors or inaccuracies, but they can reflect the noise or the artefacts introduced by the reconstruction algorithm (e.g. Gibbs over-shoots).
The mean-count polar maps are more prone to delineation errors but, if the delineation is reliable, have the advantage of depicting more accurately the distribution of activity in the LV region considered.
It is an urgent scientific question to determine if geometrical and spatial inaccuracies in SRS and FSRT are the result of delineation errors during treatment planning.
Delineation errors stay constant during the whole course of the treatment and therefore have a large impact on the dose to the tumour especially when state-of-the art radiation delivery techniques, with highly conformal beams and sharp dose gradients, are used.
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The cold walls introduce a delineation error for threshold-based delineation methods which depends on the size of the walls, the spatial resolution, and the contrast [17].
As a result, the average values of sensitivity and positive predictivity Se = 99.84% and P+ = 99.80% were obtained for the detection of QRS complexes, with the average maximum delineation error of 13.7 ms, 11.3 ms and 14.0 ms for P-wave, QRS complex and T-wave, respectively.
A commonly used and useful delineation divides radiologic error into cognitive and perceptual errors.
Even small errors in delineation can distort SUV calculations by changing the margin of the uptake regions [6], and this can eventually affect the characterization of the disease, evaluation of response to therapy, and the therapy planning.
A second element is correct delineation of the resulting error margins.
In the present study the heterogeneities of the lesions were moderate (coefficient of intensity variance of voxels within the lesions: 0.13 to 0.22) and the errors in ROI delineation were very small, but it is clear that beyond a certain degree of heterogeneity the method will fail (although such problems can be expected in only a small percentage of the practically relevant cases).
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