Further studies that aim at completely delineating the interaction between SPHK1 and PI3K/Akt will help develop new molecular targets for glioma therapy.
As a consequence, research into the mechanistic connection between apoE4 and LOAD has focused on delineating the interaction of apoE with Aß pathology.
Neurobiologically, phenotypic information may help elucidate the pathophysiology of the disease, for example, by delineating the interaction of the molecular lesion with affected neural networks (Fletcher and Warren, 2011; Rohrer et al., 2011).
A number of structural and protein RNA interactions studies for E. coli and mammalian SRPs have provided insights into the assembly of SRPs and also delineated the interaction motifs (residues) between SRP54 and SRP RNA.
Currently, a growing body of the literature is delineating the complex interaction between OVs and the tumour microenvironment that results in an additional therapeutic activity; these viruses are able to target malignancies by rapidly altering the tumour microenvironment into a milieu that potentiates anticancer activity.
Depending on the chemical exchange rate between the free and bound states of the target, affected NMR peaks, corresponding to backbone amides, can either shift, broaden their line shape or disappear completely, thereby delineating the intermolecular interaction surface between the target and the interactor(s).
Further crystallization studies are now better delineating the interaction between newly isolated potent neutralizing antibodies (PGT, PG9) and variable regions of gp120, which are critical for viral evasion of antibody neutralization.
Finally, by delineating the optimal cell-cell interaction required for the protection of stem cells from NK cell mediated cytotoxicity, we can design strategies to successfully implant either allogeneic or autologous stem cells in different tissue engineering applications.
These computational methods are important tools in delineating the molecular mechanisms involved in the interactions between biomaterials and tissue, which govern biocompatibility.
Protein interaction networks are becoming increasingly rich and useful in delineating the biological characteristics of proteins.
