As the first step to delineating the function of the genes whose expression was affected by HR overexpression, we assessed genes directly associated with HF development.
Delineating the function of all genes within the LmcDNA16 locus and their relative roles in parasite transmission will require an extended study utilizing a range of new transgenic lines expressing each gene product appropriately, both quantitatively and temporally.
This work was aimed at delineating the role of FLG loss-of-function mutations on eicosanoid metabolism in IV and AD.
Future optogenetic and targeted genetic ablation methods, such as those recently used in mammalian mesodopamine studies [ 35, 36], hold great promise for delineating the modulatory functions and behavioral effects of tonic and phasic modes of DA release in the vertebrate locomotor network.
With the enormous amount of data that these sequencing efforts are generating, it is very useful to be able to start delineating the gene function based on functional characterization of the ortholog in another species, before initiating studies in more complex organisms.
In the case of natural product research, phylogenetic relationships are proving to be highlyinformative in terms of delineating the architecture and function of the genes involved in secondary metabolite biosynthesis.
Our results delineating the tumor suppressor function of p27 will be reported elsewhere.
Roughly 30 operating manuals delineated the sundry functions of the World Trade Center -- one manual covered the machinery used to cool the buildings; another dealt with window-washing rigs; still another elaborated on the river water pumps.
Recent studies have further delineated the multiple functions of fakA as an important regulator of virulence factors [ 26] and as a fatty acid kinase responsible for host fatty acid incorporation by S. aureus [ 25].
LNSM is a powerful tool capable of delineating the architecture of functional networks underlying complex cognitive function.
