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As the first step to delineating the function of the genes whose expression was affected by HR overexpression, we assessed genes directly associated with HF development.
Delineating the function of all genes within the LmcDNA16 locus and their relative roles in parasite transmission will require an extended study utilizing a range of new transgenic lines expressing each gene product appropriately, both quantitatively and temporally.
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Active areas of current research are delineating the functions of mTOR within mTORC1 and mTORC2 (Huang and Manning, 2009) and how dysregulation of these complexes leads to human neurological disease.
Further delineating the role of IAPs in RIPK1 function, John Silke Walterr and Eliza Hall Institute, Australia) outlined findings from his lab showing that cIAPs are important regulators of RIPK1 at the tumour necrosis factor receptor 1 (TNFR1) and regulate cellular sensitivity to TNF treatment.
This work was aimed at delineating the role of FLG loss-of-function mutations on eicosanoid metabolism in IV and AD.
In addition, structure-functions studies of MC4R have delineated the role of three key acidic residues (E100A, D122A and D126A) in transmembrane regions 2 and 3 (TM2 and 3) that are critical for α-MSH binding and activation [28], [29] (Fig. 1).
With the enormous amount of data that these sequencing efforts are generating, it is very useful to be able to start delineating the gene function based on functional characterization of the ortholog in another species, before initiating studies in more complex organisms.
In the case of natural product research, phylogenetic relationships are proving to be highlyinformative in terms of delineating the architecture and function of the genes involved in secondary metabolite biosynthesis.
Our results delineating the tumor suppressor function of p27 will be reported elsewhere.
Recent studies have further delineated the multiple functions of fakA as an important regulator of virulence factors [ 26] and as a fatty acid kinase responsible for host fatty acid incorporation by S. aureus [ 25].
Roughly 30 operating manuals delineated the sundry functions of the World Trade Center -- one manual covered the machinery used to cool the buildings; another dealt with window-washing rigs; still another elaborated on the river water pumps.
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