Thus, our study delineating ATM function in NSCs may provide useful insight for development of stem cell-based novel therapies in human patients with A-T or with other genetic deficiencies that lead to neurodegeneration.
By analysing multiple distinct parameters in all mice, reliable and robust discriminatory factors delineating motor function were identified.
Delineating gene function relies on the genetic principle established by decades of genetic mapping that mutations establish causality in phenotypes.
As the first step to delineating the function of the genes whose expression was affected by HR overexpression, we assessed genes directly associated with HF development.
Delineating the function of all genes within the LmcDNA16 locus and their relative roles in parasite transmission will require an extended study utilizing a range of new transgenic lines expressing each gene product appropriately, both quantitatively and temporally.
Delineating miRNA function through knock-out and overexpression experiments in model organisms has had limited success, possibly because of functional redundancy among miRNAs or among gene pathways regulated by miRNAs [ 19].
The expression profiles of the newly identified CC-TPR proteins provide an initial working hypothesis for delineating their functions.
Active areas of current research are delineating the functions of mTOR within mTORC1 and mTORC2 (Huang and Manning, 2009) and how dysregulation of these complexes leads to human neurological disease.
Later studies, using both histochemical and nucleic acid analyses, showed the spatiotemporal expression of different ion transporters in PVCs and MRCs of fish acclimated to freshwater (FW) or seawater (SW) environments, with the aim of delineating possible functions [ 6, 7].
With the enormous amount of data that these sequencing efforts are generating, it is very useful to be able to start delineating the gene function based on functional characterization of the ortholog in another species, before initiating studies in more complex organisms.
