The genetic causes of hearing loss can be detected by sequence analysis, which helps clinicians and patients to delineate the basis of the disease.
Next generation sequencing (NGS) has provided a new paradigm in biomedical research to delineate the genetic basis of human diseases.
To delineate the molecular basis of ADI-15946's broad activity, we assigned its light and heavy chain variable domain sequences to their most probable inferred germline progenitors (IGL) (Fig. 5a and Supplementary Note 3).
Our data allow to delineate the catalytic basis for this bifunctionality, in which all catalytic residues are shared by the AMPylation and deAMPylation reactions but have different roles in catalysis.
An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process.
One approach needs to use mutant mice to delineate the molecular basis of developmental mechanisms that govern ear development, including formation and differentiation of neurons and establishment of their peripheral and central connections.
To delineate the structural basis of the auto-inhibition of Uch37 and its activation by Rpn13C, we used a Uch37 dimer model derived from its crystal structure and compared it with the structure of the binary complex of ubiquitin-bound Uch37 (PDB ID 4IG7) and its homolog UCH-L3 (PDB ID 1XD3).
Further studies are necessary to delineate the mechanistic basis of these features.
The concomitant measurement of other potentially involved molecules such as cytokines is needed to delineate the molecular basis for each NP manifestation, focusing on CSF samples.
The use of molecular modeling to delineate the structural basis for competitive inhibition of Stat3 SH2/pY-peptide binding by our compounds identified the hydrophobic binding site as a selectivity filter.
