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The REAL/WHO classification system delineates disease entities based on morphological features and immunophenotype, as well as stage of differentiation, aetiology, epidemiology and clinical behaviour.
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When used to look at all individuals, this signature did not effectively delineate disease status or atherosclerosis status (Additional file 7).
Because disease-endemic countries do not have sophisticated surveillance systems that can accurately delineate disease clusters, alternative methods such as sample-based spatial prediction need to be applied to target control programs.
Understanding the genetic architecture in autoimmunity is important to derive such target genes, and pathways and bioresources such as those outlined by Roederer et al. [ 2] could aid in the generation of new hypotheses to delineate disease mechanisms underlying autoimmunity.
Even severe hypoxemia, the cardinal feature of ARDS, does not reliably delineate disease severity or predict the development and progression of the syndrome or response to treatment in any given patient.
At the preclinical stage a number of different advances in generating either fluorescence (for example, GFP expression) or light (bioluminescence) have become powerful tools to delineate disease pathogenesis over multiple time points.
Given that there is no means available to delineate disease progression likelihood for oral lesions at earlier dysplastic stages (not analyzed here), we are also accruing serum samples from patients harboring this disease stage to determine whether our serum miRNA biomarker candidates are applicable to this patient population.
Vahedi, G. et al. Super-enhancers delineate disease-associated regulatory nodes in T cells.
We first employed linear regression to delineate disease-specific effects on methylation between cases and controls at each of the 461,272 autosomal CpGs.
To delineate the disease course and prognosis of patients with mass lesions of the fourth nerve presumed to be schwannomas.
"It appears that the writer has gone to great pains to delineate this disease, even though he didn't know what the criteria were supposed to be," Dr. Altschuler said.
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CEO of Professional Science Editing for Scientists @ prosciediting.com