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Cases and controls should be representative of the respective diseased and nondiseased persons in a well delineated target population.
We delineated target volumes on CT images with water-filled balloons and copied target volume contours to the CT images without balloons.
As for RT, treatment planning – based on a complete 3D dataset – can now be fully individualised to the patients' anatomy and the delineated target volumes, taking into account the dose to normal structures.
The PTVs and planning organs at risk volume (PRVs) were generated by the addition of a 3-mm margin to both the delineated target volume and corresponding structures (such as the spinal cord, brainstem, and optic nerve pathway).
The CT images confirmed the integrity of the BRT implant by documenting that the catheters were in still in a parallel array and covered the intraoperatively delineated target volume after the abdomen had been closed (Fig. 4a,b).
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Moreover, visual outcome showed that our method effectively delineated targeted lesions.
We have also demonstrated the usefulness of the printed subresolution sandwich phantom technique in assessing the performance of advanced PET automatic segmentation methods when delineating target objects with highly heterogeneous uptake and complex geometry.
Matsuo et al. reported that MET-PET had promising potential for precisely delineating target volumes in planning radiation therapy for postoperative patients with GBM [ 16]. Lee et al. reported the results of a study demonstrating statistically significant correlation between the presence of increased MET-PETehl uptake outside the high-dose region and subsequent noncentral failure [ 17].
The using of MR imaging can minimize the uncertainty in delineating targets and organs at risk.
That is, errors in delineating targets or OAR have significant clinical consequences given the often high doses of radiation and their proximity to healthy normal tissues [ 5].
Two plans were simulated for each patient, one with the fields designed in the conventional way based on radiological anatomy, and the other with the fields designed on the basis of a computed tomography (CT) delineated planning target volume (PTV).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com