Attempts to delineate this effect have been made in several small clinical studies.
"Very careful research will need to be done to delineate these issues".But that is not a reason for shying away from them, says Olaf Blanke of the University Hospital of Geneva, Switzerland, whose paper in the February edition of Brain describes how the brain generates out-of-body experiences.
Below, I delineate the issues raised that if satisfactorily addressed would allow us to move forward.
The physiological literature is surveyed and discussed in an effort to delineate the issues, and a tentative model of retinal response to these stimulus conditions is offered.
In the study of adoption of a well understood, complex intervention, such as home haemodialysis, a robust study methodology is important to delineate the issues facing the patients, caregivers and healthcare providers.
Although we weren't able to delineate these issues, we hypothesize that some factors, like comorbid osteoarthritis, might play an important role when the decision is made (or not) to initiate therapy.
However, as the threshold for activation signals as well as activation size can be dynamically altered by the investigator and neither a standardised approach nor a multicentre randomised clinical trial addressing this issue exists, using fMRI to delineate resection borders would in our opinion result in operating under a false sense of security and may even endanger the patient.
Hopefully, new studies will address this issue and develop specific scales to delineate the impact of VMS on mood.
A paper in this issue studied upstream substances, enzyme inhibitors, and free radical scavengers to delineate the mechanisms of Asc formation in human platelet-rich plasma (PRP).
Apropos of the article about preventive health care for patients with systemic lupus erythematosus in this issue of Arthritis Research & Therapy, we offer some thoughts about how best to delineate the roles of the specialist (rheumatologist) and the generalist in the provision of services to these patients.
