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They have the potential to inhibit the biochemical activities of a target protein, can delineate the interactions of the target protein in regulatory networks, and identify novel therapeutic targets.
Furthermore, it is important to delineate the interactions between LPCs and their niche via integrative analysis of both LPCs and their niche cells in the same developmental microenvironments.
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The test result on 17 Other-type complexes from CAPRI benchmark 1 demonstrated that the combinatorial scoring function can delineate the interaction feature of the Other-type complexes, reflect the energy change during the complex formation, and have a certain capacity to discriminate effective structures from numbers of the docked modes.
To further delineate the interaction between Usa1 and Hrd1/Hrd3, we examined these interactions in the presence or absence of one of the subunits.
To further delineate the interaction between Smad1 and ΔFosB/JunD heterodimer, we next searched binding domain of JunD to Smad1 by creating full length Flag-JunD, as well as deletion mutants of JunD, Flag-JunD(1 344) and Flag-JunD(1 321).
They should help to delineate the interaction mechanisms of calcineurin interaction with other signalling partners.
The authors use a biochemical approach to properly delineate the interaction domains of each protein.
In these studies, we have used the concept of combination therapies to delineate the interaction between OSU-03012 and lapatinib.
However, further investigations are required to delineate the interaction mechanism and regulation system involving FHL2 and AP-1 proteins.
Further studies need to be done in order to delineate the interaction between genetic factors, allergens and eosinophils.
Therefore, it is likely that a smaller portion of the IC3 is involved in the interaction with S100B and experiments were conducted to delineate the interaction site(s) more precisely.
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