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Our data also suggest that CNV analyses and resequencing studies unbiased for previous mutational burden is necessary to delineate the complexity of disease architecture.
Therefore, to obtain a more complete view of the PI3K/Akt network, it would be desirable to take an unbiased approach using quantitative MS. To delineate the complexity of the insulin signaling network, we generated dynamic maps of the insulin-regulated phosphoproteome in insulin-responsive 3T3-L1 adipocytes.
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Such variety of 'intermediate' structural snapshots also highlights the dynamics and flexibility within the conserved MAT active site, and merits further structural and biochemical studies to delineate the underlying complexity of the catalytic mechanism.
In terms of future directions, we discuss the need to delineate further the complexities of tumour vascularisation if we are to develop more effective and personalised anti-angiogenic therapies.
An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process.
This design may result in greater statistical complexity when attempting to delineate the impact of parental/support person involvement in AYA interventions.
Our model of HEG population dynamics delineates the under-recognized complexity of the evolution of selfish elements.
A spatial model incorporating ground based biodiversity attributes of the landscape elements, landuse change patterns, disturbance regimes of the landscape and terrain complexity have been used to delineate the spatial pattern of biological richness.
The binding of CTCF near +53 and upstream of the MAP17 promoter at/near the recently identified MAP17 enhancer[31], both of which have insulator enhancer-blocking activity, support this hypothesis and underlines the complexity of the compartmentalisation required to delineate the SCL regulatory domain.
It did not delineate the genders of the people affected.
And how does one delineate the contours of this "problem"?
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