The ER status of the tumors is indicated along the top of the heatmap and demonstrates that the ERA gene set can correctly delineate ER+ and ER− tumors in the independent data sets, so validating their intended capacity.
The results from our dengue cohort clearly support the contention that to correctly delineate primary and secondary responses, it is strictly necessary to combine several assays, such as IgM and IgG levels, virus isolation and/or viral RNA detection.
With respect to AMD, studies have shown that in lesions such as fibrotic scars, choroidal neovascularization disrupting the RPE, and subretinal fluid the automated segmentation algorithms would produce errors because the software would not correctly delineate the outer retinal boundary.
This indicates that although our method is generally successful in merging closely related strains of the same species into a single cluster, genetic variation between strains causes fragmentation of the species' sequence contigs in the metagenome assembly, which in turn hampers our ability to delineate this cluster correctly because smaller contigs produce a weaker and noisier Hi-C signal.
In these three patients, PET and PET/CT information served to correctly delineate the extension of a known lesion by virtue of its increased FDG uptake and to rule out further lesions that might have been missed on the ceCT images.
Using a reference standard, the ROC analysis provides information about each method evaluated to delineate which subjects are correctly identified as exercisers (true positives), correctly identified as non-exercisers (true negatives), and which subjects are misclassified (false positives and false negatives).
The use of detailed anatomy images provided by MRI combined with the ability of MRS to delineate the metabolic activity of different tissues has been found to correctly define the local tumour staging, with accuracies as high as 82 88%[ 38 40 ].
Further, using a cohort of CHD patients, we demonstrated the ability of the new method to correctly detect gain or loss of genomic material, to determine the candidate genes contributing to the disease, and to delineate the extent of the region involved in the rearrangement.
