Sentence examples for deliberate cleavage from inspiring English sources
Two recent studies have linked deliberate cleavage of late replication intermediates at fragile sites by MUS81 EME1 to genome stability in human cells (Naim et al. 2013; Ying et al. 2013).
This indicates that deliberate RF cleavage can help cells to overcome endogenous replication stress.
Deliberate RF cleavage in response to replication stress harbors the risk of illegitimate recombination and chromosomal rearrangements.
One interpretation of these findings is that deliberate RF cleavage promotes the recovery of preexisting RFs after prolonged stalling (as depicted in Fig. 3).
Although concomitant loss of WRN and MUS81 was shown to limit DSB formation in response to HU, it induced cell death, indicating that deliberate RF cleavage functions as a survival mechanism in this setting.
This could explain the apparent MUS81-dependent restart of preexisting RFs in mammalian cells after treatment with HU or CPT (Hanada et al. 2007; Regairaz et al. 2011; Ying et al. 2013), and the observation that deliberate RF cleavage under replication stress conditions can correlate with better survival.
Therefore, the replication checkpoint can be expected to antagonize deliberate RF breakage, notwithstanding that cleavage may provide an important alternative to RF preservation when arrest is irreversible (Ciccia and Elledge 2010).
Recent observations of Mus81/MUS81-dependent Mus81/MUS81-dependentwever, provide strong physichromosomece for a role in the cleavage of perturbreakss and provide new insighowevero providestrongeliberate RF breakage in eukaryotes.
