But the file of deletions is growing.
The formation of long deletions is linear with dose, as is the formation of DNA double-strand breaks.
Each gRNA generated a range of unique deletions, indicating that the process that underpins the generation of large deletions is stochastic (Fig. 1b, Supplementary Information tab 5).
In contrast, we found that a "micro-utrophin," with more extensive internal deletions, is as effective as full-length dystrophin in the regulation of actin dynamics.
Although species differences may affect DNA repair products, Ma et al.1 cannot conclude with certainty that the purported homology-directed repair gene correction event has generated homozygous wild-type embryos until the existence of large deletions is excluded.
Now, after last-minute hiccups, a constitutional amendment with 105 clauses, additions and deletions is poised for approval by a two-thirds majority of both houses of Parliament.
In this context, the differing difficulty of the individual deletions is pivotal, rather than being a challenge to text reliability (as noted by Brown 2013).
The mismapping rate and sensitivity with 10 base deletions is better than the other methods.
However, the number of atypical deletions is small and has limited such analyses.
Following this re-analysis, the HWE p-value at this locus was 1.0, indicating that the re-analysed set of deletions is in HWE.
Though the total number of possible deletions is too many for us to examine all, we did examine a small subset in analyses not detailed in this report.
