Sentence examples for deletions copy from inspiring English sources

Other mutation types such as insertions, deletions, copy number alterations, truncating and silent mutations were not considered in this analysis.

Signal intensities obtained from high-density genotyping revealed no indication for the presence of large structural variants (deletions, copy number variations) within the associated region (Additional file 2).

The application of NGS, mainly through whole-genome (WGS) and whole-exome technologies (WES), has produced an explosion in the context and complexity of cancer genomic alterations, including point mutations, small insertions or deletions, copy number alternations and structural variations.

They identified over 30,000 base substitutions - relative to a lymphoblastoid cell line from the same patient - and various other events, including insertions, deletions, copy number changes and rearrangements.

Next generation sequencing gives additional information to cancer genomics at many levels, including point mutations, insertions, deletions, copy number and translocations depending on the level of the coverage [ 23].

Array and NGS-based methods to characterize genetic variation (single nucleotide polymorphisms, short insertions and deletions, copy number variation, and structural variants), DNA methylation changes, microRNAs (miRNAs) differential expression, and other types of biological information have dramatically expanded the generation of biological data.

Currently our model only considers deletion, copy neutral, single copy or multiple copies.

Due to the high rates of origin of spontaneous duplications and deletions, copy-number changes containing the same genes arose readily in independent populations.

Such variations, including SNPs (single nucleotide polymorphisms), base insertions or deletions, copy-number variations and variable numbers of tandem repeats, can influence, and hence potentially predict, both the efficacy and toxicity of a drug.

Deletions and copy neutral LOH in 3 and 2 of the 16 cases directed us to the histone-modifying CREB-binding protein (CREBBP) gene, whose functional impairment is implicated in drug resistance.

Mechanism variants may be single base changes, small insertions or deletions (indels), copy number changes, or larger scale chromosome rearrangements.