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"We need to do something that would pass my deletion test".
Some Hughes fellows get upset, Dr. Rubin says, when he applies what he calls his "deletion test" to their research: "Would the world be very different if we eliminated all your work?" Hughes fellowships are highly prized, but the Hughes institute felt its fellowship program had grown large enough.
The significance of the increase in deviance resulting from the deletion of a variable in the model was estimated using the chi-squared deletion test [44].
Variance explained by each explanatory factor and levels of significance were calculated by using a stepwise backward deletion test (28 ).
A backward selection procedure was then applied in which parameters with t-statistic P values ≥ 0.05 and deletion test P values ≥ 0.05 were removed from the model (Crawley 2007).
For the detection of large deletions or duplications of the APC gene, Multiplex Ligation-dependent Probe Amplification (MLPA) was carried out using the SALSA P043 APC exon deletion test kit (MRC-Holland, Netherlands), following manufacturer's instructions.
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The significance of each explanatory variable in both models was analysed using deletion tests and a backward selection procedure.
Diagnostically, in young patients it is possible to use the less invasive blood samples for mtDNA deletion testing since the mtDNA molecules carrying deletions are expected to be present in all tissues due to the severe multisystem disorder.
Likelihood-ratio deletion tests were performed to test the effect of small fragment score when the effect of shot and large fragments was included in the model and vice versa.
Among the three CNVRs (PDZD2 GOLPH3 duplication, IGKV deletion/duplication, and DKK2 deletion) tested in the full Estonian sample set (Supp.
Other G/C tract amplification and deletion tests in this report used similar protocol but nested primers were not used.
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