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On the other hand, mammalian Sah1 complements a yeast sah1 deletion, providing an attractive experimental system for studies on structure function relationships (Malanovic et al. 2008; Tehlivets 2011).
Furthermore, expression changes of a Pitx2-inclusive cardiogenic sub-transcriptome were revealed downstream of calr deletion, providing novel bioinformatic support for cardiogenic disruption subsequent to calr derangement.
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Targeted gene deletion provides an excellent strategy for studying follicle biology and creating models of human reproductive disorders [1], [2].
In order to establish the role of PARP-1 in endothelial dysfunction in conscious mice, the present study determined whether PARP-1 gene deletion provides protection against endothelium-dependent (acetylcholine; ACh) and independent (sodium nitroprusside; SNP) vasodilators.
Although evaluation of proteomic changes after miRNA addition or deletion provides evidence that tools stringently requiring seed pairing perform better than those tools with more moderately stringent cutoffs [42], [43], perfect base pair matching does not guarantee interaction between specific miRNAs and target genes [35].
Ripk3 deletion provided only a modest and variable delay in the presentation of dermatitis.
The ability to evaluate well-characterized CNVs such as GSTM1 (1p13.3) deletion provides an important opportunity to assess their performance.
MMP9 deletion provided partial protection against post-MI rupture [ 138], while reducing LV dilation and dysfunction [ 139].
The determination of the actual level of the 3895 bp deletion provides an opportunity to investigate several research areas.
α -Thalassaemia: Gap-PCR (amplification across the breakpoints of a deletion) provides a quick diagnostic test for most of the known α+-thalassaemia and α°-thalassaemia deletion variants.
Such a deletion provides a close approximation to the original network if the reaction (18) has very little effect on the dynamics of the network.
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