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Along with fimA, the main structural component of type I fimbriae, hha deletion induced ihfA; ihfA is a subunit of the IHF global regulator that is required for the normal expression of fimA, as mutations in ihfA or in the IHF beta-subunit ihfB (also induced upon hha deletion) prevent the phase variation expression of fimA [11].
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The vector had sufficient stability throughout the infectious cycle and the NIb deletion prevented infection of wild-type plants which improves biosecurity.
report that Puma deletion prevents intestinal degeneration following DNA damage, thus offering a target protein for the design of enhanced cancer treatments.
Atg5 is a crucial factor in autophagosome formation as its deletion prevents their appearance [29].
Further, ablation of adult neurogenesis by irradiation or gene deletion prevents the normal behavioral response to antidepressant therapy [3], [4].
We conclude that the targeted Pink1 gene deletion prevented the generation of normal and aberrantly spliced Pink1 transcripts.
Given that its deletion prevented the association of CHIP with BAG5, we hypothesized that Hsp70 may mediate the interaction between CHIP and BAG5.
A particularly useful application has been the construction of conditional knockdown mutants as it provides a genetic approach to study genes whose deletion prevents growth or causes death of the bacteria.
Strikingly, PDK1 deletion prevents expression of these key nutrient receptors and prevents Notch-induced growth responses.
Interestingly, MerTK inactivation, but not AXL-Tyro3 double deletion, prevents prompt clearance of dying MECs.
ATG3 deletion prevents BCR-ABL1-mediated leukemogenesis in a cell transfer model.
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