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FHIT protein deletion or reduction might indicate malignant transformation.
It suggests that the degree of FHIT gene abnormal transcription and FHIT protein deletion or reduction in adrenocortical carcinoma is more serious than that in adenoma and hyperplasia.
FHIT gene abnormal transcript and FHIT protein deletion or reduction are closely linked to the malignancies of tumors in hypercortisolism of adrenocortical diseases.
Somatic changes were evident in approximately 70% of ovarian tumours, the most common being a deletion or reduction in intensity of a band suggesting loss of heterozygosity.
Deletion or reduction of AtMTP11 transcripts makes the mutant plant sensitive to elevated Mn, whereas ectopic over expression of AtMTP11 increases resistance to elevated Mn.
Deletion or reduction of histoblood group A or histoblood group B antigen in tumors of A or B individual is correlated with the degree of malignancy and metastatic potential in many types of human cancers.
Similar(53)
Many of the integrated retroviruses (proviruses) became defective due to accumulation of nonsense mutations, large internal deletions, or reduction to so-called solitary LTRs after homologous recombination within a provirus [for reviews, see [ 1- 4]].
Acute challenge with the NMDAR antagonist MK-801 induced cognitive deficits in wild-type mice comparable to documented impairments reported in mice with genetic deletions or reductions in the NMDAR subunits NR1, NR2A, or NR2C.
Similar to Organ et al. (2007), we suggest that although genome size reduction in reptiles may have occurred before the origin of powered flight in birds and bats, flight nonetheless further reduced genome size in these lineages, leading to further reductions in of intron sizes, likely through biased deletion or ultimately through reduction of cell volume (Johnson 2004).
Clearly, a thorough analysis of the metabolic pathways that are altered by the deletion and/or reduction of Indy/CeNAC2 are needed to better understand how AMPK/aak2 might be activated.
On soybean oil, fadB′ deletion led to reduction of PHA quantity attributed to decrease of 3HB unit, while fadB1 deletion slightly increased 3HHx composition without serious negative impact on both cell growth and PHA biosynthesis.
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