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Deletion or alteration of this motif induced trafficking impairment in both in vitro systems and animal models, the latter one accompanied by photoreceptor cell death, displaying its very important role for transport to the membranous rod outer segment (ROS) [14] [16].
Moderate effect variations (36 087) included the ones which change coding region by insertion, deletion or alteration of the codon.
2) Does deletion or alteration of subregion V in Ire1 and Perk affect the binding of their luminal regions to BiP in cells?
See section "BiP deletion mutants that lack substrate binding domain attenuate UPR signaling" and Figure 6. 2) Does deletion or alteration of subregion V in Ire1 and Perk affect the binding of their luminal regions to BiP in cells?
Deletion or alteration of the character of these sequences in dystroglycan was sufficient to prevent the association of ezrin with dystroglycan and prevented dystroglycan-induced actin-rich protrusions [ 50, 55].
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In Wilms' tumours, mutation of the Wilms tumour 1 (WT1) gene at the WT1 locus has been reported, and the WT2 locus, comprising the two independent imprinted domains IGF2/ H19 and KIP2/ LIT1, can undergo maternal deletion or alterations associated with imprinting.
Thus, recombination events can lead to deletions or alterations in the structure of these genes and therefore altered expression [ 12].
During batch calculations, only small changes to the optimisation problem are required, e. g., changes of variable bounds in an in silico gene deletion experiment, or alteration of the objective function during flux variability analysis.
For that purpose, the targeted deletion or functional alteration of miRNA function, followed by monitoring of cognitive functions, would be more appropriate.
A PCR-based survey of materials from the population indicated that the FaFAD1 genomic sequence could not be amplified from γ-D non-producers, suggesting gene deletion or radical alteration affecting PCR amplification.
In this study, however, genomic analysis of NORE1 revealed that deletion or sequence alteration of NORE1 is very rare in cancers, suggesting that genomic deletion of the gene might not be a main cause leading to loss or abnormal reduction of its expression in colorectal cancers.
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