Sentence examples for deletion of essential from inspiring English sources

These conditional knockout (CKO) mice are not only desired when embryonic lethality caused by deletion of essential genes, but also are better models for human diseases.

We have developed a genetic complementation system that enables the deletion of essential viral genes from the MVA genome, thereby allowing us to generate MVA vaccine vectors that are antigenically less complex.

In the present study, we describe the establishment of a genetic system to complement deletion of essential MVA genes and its use to create a recombinant MVA from which the uracil-DNA-glycosylase gene has been deleted.

Homologous recombination in mouse ES cells transfected with the targeting vector (construction described in the Methods) led to the replacement of Pink1 exons 4 and 5 with a phosphoglycerate kinase (PGK) promoter-driven neomycin phosphotransferase (neo) expression cassette and the deletion of essential portions of the PINK1 kinase domain (Figure 1).

The lack of a dependable inducible knockout system in the P. falciparum system, combined with the haploid genome of asexual parasite stages makes it currently impossible to study the effect of deletion of essential genes, or those conferring a massive growth disadvantage.

We suggest that the ability to tolerate deletion of essential cell division genes such as ftsZ will be a useful operational test for the true L-form state.

The antiaging effect of spermidine was abolished by the deletion or depletion of essential autophagy genes in yeast, Drosophila and C. elegans [ 96].

Pseudomonas aeruginosa strains carrying deletions of essential genes were engineered to be dependent on the isopropyl-β-D-thiogalactopyranoside (IPTG -regulated expressIPTG -regulated psexpression oftheirgues on a B.oad-host-range pseudomallei

Among these recent results are the description of tissue specific deletions of essential autophagy genes in liver, brain, pancreas and heart [ 9- 14].

Samanta et al [ 7] and Davis et al [ 8] used tiling arrays to analyze the effect of deletions of essential RNA processing proteins on the yeast transcriptome.

For example, deletion of the ku70 homologous gene kusA in Aspergillus niger resulted in a recipient strain in which deletions of essential or non-essential genes can efficiently be obtained.