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There was no impact of the alpha-globin 3.7 deletion (comparing wildtype with heterozygote plus homozygote deletion groups) on gametocytes in any study site (Table 4).
For analysis, the homozygous deletion and heterozygous deletion groups were combined.
Both Xp and Xq deletion groups were heterogeneous for ovarian failure, so we tested for an association between this phenotype and TSCS score among all 47 subjects.
However, the biological difference between the high‐ and low‐level homozygous deletion groups and the clinical significance of p16 heterozygous deletion dominancy remain unclear.
But, as we move towards larger size deletion groups (21 40, 41 60, 61 80 Mb), a highly significant negative correlation between proportion of deletions and number of marker loci mapped on a particular chromosome was observed.
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In the deletion group, however, 38% of patients did not fulfil four or more major criteria.
54 There is a higher incidence of microcephaly in the deletion group compared with non-deletion subtypes.
Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group.
In contrast, there was no association between low BRCA1 expression and these ER-negative PAM50 subtypes in the BECN1 deletion group (Fig. 1J, Fig. 2J).
Similarly, we detected a trend towards significance (P = 0.071) when comparing patients with TP53 and 13q deletions, which might be due to the small number of cases in the TP53 deletion group.
The mean TSCS score of the Xp deletion group was similar to that of the 45, X TS group and differed from that of the Xq and control groups (P < 0.05, Tukey test).
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