Sentence examples for deletion challenge from inspiring English sources

The first scenario in our study mimics a gene deletion challenge.

In addition, the particularly poor prognosis of patients with HER2 amplification and PTEN deletions challenges the concept of PTEN deletions interfering with trastuzumab therapy.

Prioritizing which nuclear-encoded mitochondrial maintenance genes to screen in adults with multiple mitochondrial DNA deletions is challenging.

Since copy-number changes are relative for array CGH data, unambiguous ascertainment of the ancestral state of a CNV and (subsequent) identification of duplications and deletions is challenging.

However, predicting the phenotype of an individual based solely on the location and extent of their 1p36 deletion remains a challenge since most of the genes that contribute to 1p36-related phenotypes have yet to be identified.

We have established that the optimal in silico target gene deletion problem is challenging, by showing that a nonlinear integer programming formulation of the GKO problem based on the DDS model is NP-hard.

However, recognizing the relevant single nucleotide variants, small insertions and deletions remains a challenge for many researchers and diagnostic laboratories typically do not have access to the bioinformatic analysis pipelines necessary for clinical application.

While this strategy indeed conferred excellent protection against subsequent challenge, the deletion of antigenic virulence determinants may reduce potential efficacy as protective epitopes are lost.

While large genomic deletions have already been found and replicated, the problem of identifying small deletions remains an unmet challenge.

The low frequency or absence of methylation in critical TSG genes commonly inactivated by mutation or deletion in MCL has challenged the role that DNA methylation might play in MCL lymphomagenesis [2].

This cysteine requirement, however, made the investigation of the oxidation status of proteins in Δ trr1 strains very difficult, and the interpretation of the effects of a ttr1 deletion on lifespan very challenging.