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These assumptions have been particularly deleterious to the development of treatments with mechanisms distinctly different from currently approved treatments.
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High concentrations of sodium in soils are deleterious to the growth and development of non-halophytes.
Additionally, our findings support the hypothesis that cadmium exposure might be deleterious to fetal development.
We also demonstrate negative selection of mutations that may be deleterious to tumor development indicating novel avenues for therapy.
For several Australian temperate sea urchin species, a 3°C increase in temperature is deleterious to early development (Byrne 2012; Foo et al. 2012).
In contrast, later onset (E11.5) of PHOX2B∆8 expression was not deleterious to LC development and perinatal respiratory lethality was rescued, despite failure of chemosensor retrotrapezoid nucleus formation.
Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet to be designed.
This concept of an evolutionary basis for the development of age-related diseases postulates that genes that are beneficial during the reproductive phase of life may become deleterious to development later on.
Until recent decades, bilingualism was deeply frowned upon and considered deleterious to development.
RNH may have deleterious long-term consequences related to the development of portal hypertension.
However, the activation of MPO may become deleterious and can also contribute to the development of cardiovascular diseases (Nicholls & Hazen 2005, Podrez et al. 2000, Klebanoff 2005).
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