These assumptions have been particularly deleterious to the development of treatments with mechanisms distinctly different from currently approved treatments.
Additionally, our findings support the hypothesis that cadmium exposure might be deleterious to fetal development.
For several Australian temperate sea urchin species, a 3°C increase in temperature is deleterious to early development (Byrne 2012; Foo et al. 2012).
In contrast, later onset (E11.5) of PHOX2B∆8 expression was not deleterious to LC development and perinatal respiratory lethality was rescued, despite failure of chemosensor retrotrapezoid nucleus formation.
High concentrations of sodium in soils are deleterious to the growth and development of non-halophytes.
Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet to be designed.
In contrast, ubiquitous expression of Ndi1, the alternative NADH dehydrogenase from yeast, was highly deleterious to tko 25t during development and was lethal when combined with both tko 25t and AOX.
Prognosis remains poor due to deleterious development of multidrug resistance resulting in less than 15% lung cancer patients reaching five years survival.
Although initial use of platin-based cytotoxic chemotherapy improved the overall survival rate and life quality of the patients, the outcome remains poor due to deleterious development of drug resistance resulting in less than 15% lung cancer patients surviving for at least five years [ 2, 3].
Endocrine disrupting chemicals (EDCs) have been proven to have potentially deleterious effects on development, growth, metabolism, and reproduction as they can interfere with the production, release, transport, metabolism, binding, action, or elimination of the natural hormones in the body [ 1].
