In some cases, supraphysiologically high loadings are used to achieve therapeutic local concentrations, but uncontrolled release can then cause deleterious off-target side effects.
Targeting of fibrosis via TGF-β musthereforere be carefully considered in the context of the whole patient, with emphasis on minimizing deleterious off-target effects.
Additional file 5: Prediction of Deleterious Alleles in Target Amplicons (PoDATA) program.
Moreover, recent technological advances allow other methods, such as TaGTEAM and gTME, to generate 'semi-random' diversity, where an enormous number of different mutations can be introduced in a specific genomic region, thereby limiting the risk of off-target deleterious mutations that result in crippled strains.
Current cancer chemotherapeutics are significantly limited by a lack of selectivity for the intended target and deleterious side effects.
The advanced method in computational biology has now enabled us to determine the deleterious nsSNPs in the target candidate genes.
Preventive efforts should target the deleterious effects of added sugars by providing viable alternatives to sugar-sweetened beverages and making it easier for individuals to access fluorides and other types of preventive care that helps to control tooth decay.
Circulating MPs from septic patients might exert a protective role at the vascular level by compensating hyporeactivity [ 6], but they might also contribute to the cause of multiorgan failure in sepsis and induce deleterious protein changes in target tissues [ 7].
The mutational-burden hypothesis asserts that noncoding DNA (i.e., intronic and intergenic DNA) is a genetic liability because it is a target for deleterious and potentially lethal mutations, such as mutations affecting sequences involved with intron splicing and gene regulation.
