Sentence examples for deleterious state from inspiring English sources
These genetic factors might unbalance the fine-tune regulation toward a hyper-inflammatory deleterious state.
21, 22 Cardiovascular integrator markers are quantifiable parameters reflecting the deleterious state caused by risk factors and are linked to the occurrence of clinical events.
Conduit artery (in particular aortic) mechanical properties are considered markers of vascular health, with increased stiffness considered an indicator of a more deleterious state.
The aim of this therapy would be to drive those pathways to a non-pathological state or at least, to a less deleterious state.
The "sub_family_conservation" predicate was found in all the rules in these two subfamilies and was highly predictive for the deleterious state.
At present, research efforts to unravel SS tend to focus on mechanisms underlying lymphocytic infiltration of the salivary gland, as such infiltration is pathognomonic and thus a reasonable candidate for an advanced deleterious state upon which multiple pathways converge.
Accordingly, substance S is subject to natural selection, which means that the pace of accumulation of substance S can be manipulated by natural selection to postpone or forestall the action of potentially deleterious state-specific genes (Fig. 1).
First, there is no independent time-keeping mechanism, which means that potentially deleterious state-specific genes cannot be thought of as independent from the somatic change on which their activation relies.
The greater the number, severity, or sensitivity to somatic change of potentially deleterious state-specific genes ('state-specific load'), the greater the deterioration that results if the somatic change triggers those state-specific genes, and the stronger natural selection will act against this somatic change.
It is these last copies that are then slowly degraded by Muller's ratchet, since they can most probably mutate to such slightly deleterious states that allow the operation of the ratchet.
A key idea is that activation of microglia to highly deleterious states depends on the sequential appearance of at least two hits, the first one rendering microglia mildly activated, thus priming its response to ensuing hits.
