Sentence examples for deleterious sites from inspiring English sources

The observed correlation between substitution rates at neighbouring non-synonymous and synonymous sites could arise by hitchhiking effects, in which selection increases the fixation probability of linked weakly deleterious sites [48].

These results show that purifying selection further facilitates the purging of deleterious sites in a growing population.

If IRs at deleterious sites are removed by selection, an abundance that is concentrated at the sites where they are not deleterious would result.

Before we can estimate U sdm, we need to estimate U tot, the mutation rate at all potentially deleterious sites in a haploid genome per generation.

The total mutation rate U TOT at potentially deleterious sites can be computed from the observable per base pair mutation rate per generation, μ, and from the mutational target size G.

In addition, although it decreases the proportion of segregating sites lost in each DAC category, the larger size of the growing population improves the efficacy of natural selection, and deleterious sites are more readily eliminated.

We partitioned genotypes in our data into those occurring at deleterious versus non-deleterious sites and those occurring outside or inside ROH regions for the given ROH size.

Additional file 11: Table S2 and Additional file 12: Table S3 show the counts for reference homozygotes (0/0), heterozygotes (0/1), and non-reference homozygotes (1/1) at deleterious and non-deleterious sites, respectively, that were contained within ROH and non-ROH regions (all g i, j d, k and g i, j n, k ).

Alternative explanation, concerning natural selection, would be that the small historical population size of humans has reduced the efficiency of purifying selection, which enabled the mildly deleterious synonymous sites to escape the purifying selection among humans but not in chimpanzees.

However, proliferation of MECs can become deleterious at sites of confined CSF space, such as the subarachnoid space of the optic nerve [16], as the width of the subarachnoid space here measures only about 0.3 mm and is further restricted through numerous trabeculae and septa.

Despite the accumulation of deleterious segregating sites in the growing population, we show a stronger increase in the average fitness effect of derived alleles in the growing population.