Sentence examples for deleterious sequences from inspiring English sources

Assuming that nullomers are the signatures of natural selection against deleterious sequences in humans, the use of nullomers in drug target identification, pesticide development, environmental monitoring, and forensic applications has been envisioned.

The three potentially deleterious sequences were introduced back into the oACHE-S sequence in an analogous way.

A low level of expression is ideal for purging strongly deleterious sequences, whereas benign sequences remain effectively neutral (Masel 2006; Rajon and Masel 2011).

This implies that the three potentially deleterious sequences (the two 5'-intron splice sites and the polyadenylation sequence) do not play a major role in this case.

Similarly, the two 5'-intron splice signals were mutated in pTM152 to yield pTM157, resulting in a hACHE-S variant lacking all three potentially deleterious sequences.

Please note that our optimization strategy did not eliminate all infrequently used codons, giving preference to the elimination of all other deleterious sequences.

We interpret these results to mean that codon usage is a strong determinant of the overall expression level that can be obtained from a gene, but that this level can be reduced if deleterious sequence elements are present, for example those that form mRNA structures that may interfere with the initiation of translation.

39 Individuals carrying deleterious sequence changes in RERE have not been reported.

Eight of these samples were found to carry putatively deleterious sequence changes in PRDM16.

To facilitate the identification of deleterious sequence variants, MU2A annotated variants with conservation score, gene function, pathway information and impact on protein function (refer to Supplementary Material).

A further 345 women from the same ethnic origin were stated to be recruited to assess allele frequency for potentially deleterious sequence variants.